Search | Global Index Medicus

1.

Inhibition of in vitro DNA synthesis by metepa--an aziridinyl alkylating agent.

Saxena, D M; Pillai, M K; Shivaji, S.

Indian J Exp Biol ; 1984 Aug; 22(8): 453-4

Article in English | IMSEAR | ID: sea-59076

Subject(s)

Animals , Azirines/pharmacology , Cattle , DNA Polymerase I/metabolism , DNA Replication/drug effects , Escherichia coli/enzymology , Mutagens/pharmacology

2.

Plasmodium falciparum infection in Bisazir chemosterilized Anopheles dirus in laboratory studies.

Sucharit, S; Kerdpibule, V; Chomcharn, Y; Limsuwan, S.

Southeast Asian J Trop Med Public Health ; 1984 Jun; 15(2): 228-33

Article in English | IMSEAR | ID: sea-35906

ABSTRACT

Bisazir, at a 0.5% solution induced sterility in males and at a 1.5% solution in female A. dirus. These sterilizing doses reduced P. falciparum infection in mosquitoes, however, they can still transmit malaria. It is concluded that by the concentration of 1.5 and 2.0% that induced complete sterility in males and females are not safe in sterile-male release programme for the control of A. dirus, unless all females were eliminated prior to release.

Subject(s)

Animals , Animals, Laboratory , Anopheles/drug effects , Aziridines/pharmacology , Azirines/pharmacology , Crosses, Genetic , Female , Fertility/drug effects , Male , Oviposition/drug effects , Plasmodium falciparum/growth & development , Pupa/drug effects

3.

Effect of BM 12531 on rosette formation and in vitro functions of peripheral blood lymphocytes obtained from healthy donors and cancer patients.

Advani, S H; Ghogale, S R; Gangal, S G.

Article in English | IMSEAR | ID: sea-20196

Subject(s)

Aziridines/immunology , Azirines/pharmacology , Hodgkin Disease/immunology , Humans , Leukocyte Migration-Inhibitory Factors/biosynthesis , Multiple Myeloma/immunology , Rosette Formation , T-Lymphocytes/drug effects

4.

Effects of tepa on alkaline phosphatase activity during ovarian development of the tropical house mosquito Culex pipiens fatigans Wiedemann.

Kawatra, V K.

Indian J Exp Biol ; 1981 Mar; 19(3): 212-5

Article in English | IMSEAR | ID: sea-60292

Subject(s)

Alkaline Phosphatase/metabolism , Animals , Azirines/pharmacology , Culex/enzymology , Female , Ovary/drug effects , Pupa/enzymology , Triethylenephosphoramide/pharmacology

5.

Effect of apholate (ENT 26316; NSC 26812) on nucleic acids, total protein content & activity levels of aminotransferases (GOT, GPT), alkaline phosphatase & 5'-nucleotidase in liver of male albino rats.

Haqqi, T M; Adhami, U M.

Indian J Exp Biol ; 1979 May; 17(5): 488-92

Article in English | IMSEAR | ID: sea-58538

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , DNA/metabolism , Liver/drug effects , Male , Nucleic Acids/metabolism , Nucleotidases/metabolism , Phosphoric Monoester Hydrolases/metabolism , Proteins/metabolism , RNA/metabolism , Rats , Transaminases/metabolism

6.

Effect of apholate on neurosecretion of pars intercerebralis, fat bodies & ovarian development of the red cotton bug Dysdercus koenigii (F).

Taneja, S K; Sood, V; Taneja, S; Nath, A.

Indian J Exp Biol ; 1979 Feb; 17(2): 133-8

Article in English | IMSEAR | ID: sea-57899

Subject(s)

Adipose Tissue/drug effects , Animals , Aziridines/pharmacology , Azirines/pharmacology , Female , Hemiptera/drug effects , Neurosecretory Systems/drug effects , Ovary/drug effects

7.

Combined cytogenetic effects of endosulfan & metepa in male rats.

Dikshith, T S; Nath, G; Datta, K K.

Indian J Exp Biol ; 1978 Sep; 16(9): 1000-2

Article in English | IMSEAR | ID: sea-57812

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , Chromosome Aberrations/drug effects , Endosulfan/pharmacology , Male , Rats

8.

Mode of action of alkylating agents using a ciliate protozoan as a model system: Part V--effect of metepa on protein synthesis in Blepharisma intermedium (Ciliata).

Shivaji, S; Saxena, D M; Pillai, M K.

Indian J Exp Biol ; 1978 Jun; 16(6): 632-5

Article in English | IMSEAR | ID: sea-55765

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , Ciliophora/drug effects , Depression, Chemical , Protein Biosynthesis

9.

Effect of apholate (NSC 26812; ENT 26316) on the nucleic acids & protein content in the spleen of male albino rats.

Haqqi, T M; Adhami, U M.

Indian J Exp Biol ; 1978 Jun; 16(6): 720-2

Article in English | IMSEAR | ID: sea-56247

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , DNA/analysis , Depression, Chemical , Male , Proteins/analysis , RNA/analysis , Rats , Spleen/analysis

10.

Effect of metepa on the reproductive potential of albino rat.

Nirmala, M; Adhami, U M.

Article in English | IMSEAR | ID: sea-19408

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , Depression, Chemical , Female , Fertility/drug effects , Litter Size/drug effects , Male , Pregnancy , Rats

11.

Mode of action of alkylating agents using a ciliate protozoan as a model system: Part III--Effects of metepa on cell division & DNA synthesis in the ciliate Belpharisma intermedium.

Shivaji, S; Saxena, D M; Pillai, M K.

Indian J Exp Biol ; 1978 Apr; 16(4): 450-4

Article in English | IMSEAR | ID: sea-63213

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , Cell Division/drug effects , Ciliophora/cytology , DNA/biosynthesis , Depression, Chemical

12.

Mode of action of alkylating agents using a ciliate protozoan as a model system: Part IV--effect of metepa on the synthesis of RNA in the ciliate Blepharisma intermedium.

Shivaji, S; Saxena, D M; Pillai, M K.

Indian J Exp Biol ; 1978 Apr; 16(4): 455-7

Article in English | IMSEAR | ID: sea-60210

Subject(s)

Animals , Aziridines/pharmacology , Azirines/pharmacology , Ciliophora/drug effects , Depression, Chemical , RNA/biosynthesis

13.

Cytogenetic basis of chemically induced sterility in Culex pipiens fatigans Wiedemann. 3. Effect of apholate & hempa on DNA synthesis in the gonads.

Grover, K K; Pillai, M K; Dass, C M.

Indian J Exp Biol ; 1971 Apr; 9(2): 150-2

Article in English | IMSEAR | ID: sea-62534

Subject(s)

Animals , Azirines/pharmacology , Chemosterilants/pharmacology , Culex/drug effects , Cytogenetics , DNA/biosynthesis , Female , Gonads/drug effects , Larva/drug effects , Male , Ovary/metabolism , Phosphoranes/pharmacology , Phosphoric Acids/pharmacology , Sterilization, Reproductive , Testis/metabolism , Thymidine/metabolism , Tritium

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